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KMID : 0881720180330020140
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Journal of Food Hygiene and Safety
2018 Volume.33 No. 2 p.140 ~ p.145
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Antioxidant and Anti-aging Effects of Extracts from Leaves of the Quercusaliena Blume on Human Dermal Fibroblast
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Choi Sun-Il
Lee Jong-Seok
Lee Sa-Rah
Yeo Joo-Hong
Jung Tae-Dong
Cho Bong-Yeon
Choi Seung-Hyun
Sim Wan-Sup
Han Xionggao
Lee Jin-Ha
Kim Jong-Dai
Lee Ok-Hwan
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Abstract
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The skin of the human body occupies the largest surface area of the body and acts as a protection for the person’s internal organs. As such, the skin is a major target of oxidative stressors, and these oxidative stressors are known to contribute to skin aging over the course of time. For the most part, an antioxidant is an effective approach to utilize to prevent symptoms related to the reactive oxygen species (ROS)-induced aging of the skin. Therefore, we investigated the antioxidant and anti-aging activity of the leaves of the Quercusaliena Blume extract (QBE). In our study, we confirmed that the cell viability tested with XTT {2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide innersalt} assay was not affected up to a concentration of 100 μg/mL. In addition, the cell viability of HDF cells induced by hydrogen peroxide was recovered from 81% to 104% after treatment with QBE, which showed the greater protective effect than that of ascorbic acid. Treatments of QBE dose-dependently inhibited reactive oxygen species (ROS) production in HDF cells induced by hydrogen peroxide, which correlated with their protective effects on cell viability. Since QBE treatment exhibited the suppression effect of skin aging by decreasing the ROS production, QBE could be used as a not only natural anti-aging but also antioxidant resource.
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KEYWORD
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Rreactive oxygen species , Human dermal fibroblast , Antioxidant , Anti-aging
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